Grant: Project Grant

Hemorrhagic transformation is a type of bleeding into the brain that occurs in patients with ischemic stroke. When this bleeding occurs it further damages the brain tissue that has already been injured by stroke. This additional damage increases stroke disability, worsens stroke outcomes, and increases mortality. Methods to prevent hemorrhagic transformation are needed to improve recovery for patients who suffer a stroke. The study will focus on human stroke and is therefore directly relevant to patients. The study will show how a specific molecule promotes hemorrhagic transformation. It will demonstrate how targeting this molecule can be a treatment to prevent this type of bleeding in the brain. This new treatment will be a major step forward to improve outcomes in patients with stroke.