Grant: Knowledge Synthesis Grant

Depression is common in multiple sclerosis (MS). Fully half of MS patients can expect to be depressed at some point in their lives. This compares with 10-15% in the general population, and 15-25% in other serious diseases such as heart disease and cancer. Although depression in MS has received a good deal of attention in the published literature, findings and conclusions of studies are often conflicting. Uncertainty remains about why rates of depression are so high in this population. Questions also remain about the relative importance of physical, psychological and social/environmental factors in the cause and prognosis of depression in MS. Thus, to clarify the existing evidence on depression in MS and to appraise and synthesize our current knowledge in this area, we are proposing a systematic review of the literature in this area to answer the following questions. How common is depression in persons with MS and what are the physical, psychological and social/environmental risk factors for becoming depressed? How does depression affect health and well-being outcomes in persons with MS? We also want to identify gaps in our knowledge about depression in MS. By systematically searching for the available studies, critically appraising those studies and drawing conclusions based on the best evidence, researchers can move forward purposefully by filling in the gaps in knowledge. At the same time, clinicians can use what is known to identify those most likely to develop depression, and to work towards successful prevention and management of depression in MS. Finally, those with MS will better understand whether they are at risk of developing depression, and they and their families will have better knowledge of how to prevent and or manage depression.