Grant: CIHR-ICRH Travel Awards - ICRH / Vascular pool
University of British Columbia
$1,500.00
The Clinical Utility and Ancestral Diversity of Polygenic Risk Scores in Cardiometabolic Disease Risk Prediction
FY 2023-24
Summary
A polygenic risk score (PRS) estimates an individual’s genetic risk for a specific disease at birth. Cardiometabolic diseases have disproportionally affected underrepresented racial and minority groups. These groups are generally not well captured by traditional risk scores compared to European cohorts. PRSs have increasingly been seen as a promising tool to improve risk stratification of non-European populations. However, how PRSs can be best used in clinical practice remains unclear. We provide an overview of the PRSs related to cardiometabolic disease and the evidence supporting PRS application in diverse populations.
Department
Program
CIHR-ICRH Travel Awards - ICRH / Vascular pool
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
495440
Name
Phulka Jobanjit S
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Prcname2
Special Cases
Projecttitle
The Clinical Utility and Ancestral Diversity of Polygenic Risk Scores in Cardiometabolic Disease Risk Prediction
Programtype2
Undefined
Orgnameinp2
University of British Columbia
Cihramount2
$1,500
Cihrequipment2
$0
Programname2
CIHR-ICRH Travel Awards - ICRH / Vascular pool
Keyworddelim
Ancestral Diversity; Cardiometabolic Disease; Polygenic Risk
Abstract
A polygenic risk score (PRS) estimates an individual’s genetic risk for a specific disease at birth. Cardiometabolic diseases have disproportionally affected underrepresented racial and minority groups. These groups are generally not well captured by traditional risk scores compared to European cohorts. PRSs have increasingly been seen as a promising tool to improve risk stratification of non-European populations. However, how PRSs can be best used in clinical practice remains unclear. We provide an overview of the PRSs related to cardiometabolic disease and the evidence supporting PRS application in diverse populations.
Competitiondate
202309
Approvedterm2
1 yr 0 mth
Pinamesdelim
Phulka, Jobanjit S
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $1,500~ $0~
