Grant: DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)
University of British Columbia
$120,000.00
Dormancy-Capable Cells Drive Prostate Cancer Relapse: Mechanisms and Clinical Implications
FY 2025-26
Summary
Prostate cancer is a common and serious disease affecting many men worldwide. While hormone treatments can shrink tumours, some cancer cells go into a "sleeping" or dormant state, making them hard to detect and treat. These dormant cells can later wake up and cause the cancer to come back, often in a more aggressive form. Our research focuses on understanding this special group of cancer cells and preventing them from causing prostate cancer recurrence. By studying these dormant cells in detail using advanced technologies that look at individual cancer cells, we aim to discover how they survive treatment and cause recurrence. We will investigate their unique features and survival strategies. The knowledge gained will help us find new ways to identify patients at higher risk of relapse and guide the development of treatments that specifically target dormant cells before they cause the cancer to return. Furthermore, the findings may have broader implications for other types of cancer where dormant cancer cells lead to disease recurrence. Ultimately, this research supports the development of more personalized and effective cancer therapies, helping healthcare systems deliver better outcomes for patients.
Department
Program
DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
560027
Name
Classen Adam
Region
British Columbia
Country
Canada
Orgtype
Research Institution; Institution Paid
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
DT1 (Biomedical and/or Clinical Research) CGRS Doctoral
Projecttitle
Dormancy-Capable Cells Drive Prostate Cancer Relapse: Mechanisms and Clinical Implications
Programtype2
Studentship Programs
Orgnameinp2
University of British Columbia
Cihramount2
$120,000
Cihrequipment2
$0
Programname2
DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)
Keyworddelim
Prostate Cancer; Single-Cell Rna Sequencing; Tumor Dormancy
Abstract
Prostate cancer is a common and serious disease affecting many men worldwide. While hormone treatments can shrink tumours, some cancer cells go into a "sleeping" or dormant state, making them hard to detect and treat. These dormant cells can later wake up and cause the cancer to come back, often in a more aggressive form. Our research focuses on understanding this special group of cancer cells and preventing them from causing prostate cancer recurrence. By studying these dormant cells in detail using advanced technologies that look at individual cancer cells, we aim to discover how they survive treatment and cause recurrence. We will investigate their unique features and survival strategies. The knowledge gained will help us find new ways to identify patients at higher risk of relapse and guide the development of treatments that specifically target dormant cells before they cause the cancer to return. Furthermore, the findings may have broader implications for other types of cancer where dormant cancer cells lead to disease recurrence. Ultimately, this research supports the development of more personalized and effective cancer therapies, helping healthcare systems deliver better outcomes for patients.
Competitiondate
202511
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Classen, Adam
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $120,000~ $0~