Grant: Project Grant
Research Institute of the McGill University Health Centre
$477,815.00
Unmasking brain injury: Ultra high-resolution, distortion-free, unobstructed imaging of grey matter in mild and moderate traumatic brain injury using multi-echo techniques
FY 2015-16
Summary
Concussions clearly cause brain injury because patients report many severe symptoms. Bizarrely, the symptoms are rarely corroborated by MR imaging, which almost always appears normal even in symptomatic patients. While the exact reasons for the discrepancy are not known, we think there are at least three factor involved: (1) brain injury frequently occurs near bony tissue, and bone minerals cause MRI signals to decay very quickly
(2) brain injury may be subtle and a small change--0.5mm--which is substantial for cell loss, may be impossible to detect with current 1mm resolution imaging methods and
(3) the dura--the tough sac that surrounds the brain--is indistinguishable from grey matter near bony tissue, thus causing serious errors in grey matter estimates.
Department
Program
Project Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
345689
Name
Farivar-Mohseni Reza
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Unmasking brain injury: Ultra high-resolution, distortion-free, unobstructed imaging of grey matter in mild and moderate traumatic brain injury using multi-echo techniques
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$477,815
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Concussion; Grey Matter; Low Distortion; Mild Tbi; Mri; Multi-Echo; T1; Tbi; Traumatic Brain Injury; Ultra High-Resolution
Abstract
Concussions clearly cause brain injury because patients report many severe symptoms. Bizarrely, the symptoms are rarely corroborated by MR imaging, which almost always appears normal even in symptomatic patients. While the exact reasons for the discrepancy are not known, we think there are at least three factor involved: (1) brain injury frequently occurs near bony tissue, and bone minerals cause MRI signals to decay very quickly
(2) brain injury may be subtle and a small change--0.5mm--which is substantial for cell loss, may be impossible to detect with current 1mm resolution imaging methods and
(3) the dura--the tough sac that surrounds the brain--is indistinguishable from grey matter near bony tissue, thus causing serious errors in grey matter estimates.
Competitiondate
201603
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Farivar-Mohseni, Reza; Levesque, Ives R
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $477,815~ $0~
