Grant: Operating Grant
McMaster University
$351,765.00
TDAG51 in vascular calcification associated with chronic renal disease
FY 2010-11
Summary
Cardiovascular disease (CVD) is the major cause of death in patients suffering from chronic kidney disease (CKD). Over half of all deaths in patients with end-stage renal disease result from CVD, with mortality rates 10 to 30-fold greater than in the general population. Calcification of the blood vessel wall is a major feature of CKD and is now recognized as an important predictor of cardiovascular disease. The purpose of these studies is to explain the role of TDAG51 in the development and progression vessel calcification. By better understanding how TDAG51 modulates vessel calcification, we will have a unique opportunity to develop novel drugs that decrease the accumulation of calcium in the blood vessel.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
210368
Name
Austin Richard C
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Cardiovascular System - B: Heart and Circulation
Projecttitle
TDAG51 in vascular calcification associated with chronic renal disease
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$351,765
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Apoptosis; Cardiovascular Disease; End Stage Renal Disease; Smooth Muscle Cells; Tdag51; Vascular Calcification
Abstract
Cardiovascular disease (CVD) is the major cause of death in patients suffering from chronic kidney disease (CKD). Over half of all deaths in patients with end-stage renal disease result from CVD, with mortality rates 10 to 30-fold greater than in the general population. Calcification of the blood vessel wall is a major feature of CKD and is now recognized as an important predictor of cardiovascular disease. The purpose of these studies is to explain the role of TDAG51 in the development and progression vessel calcification. By better understanding how TDAG51 modulates vessel calcification, we will have a unique opportunity to develop novel drugs that decrease the accumulation of calcium in the blood vessel.
Competitiondate
201009
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Austin, Richard C
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $351,765~ $0~
