Grant: Project Grant
University of Ottawa
$875,926.00
Identification of VHL-dependent dysfunction of the retinoblastoma protein in renal cancer RUNNING TITLE: Characterization of pRb dysfunction in RCC
FY 2021-22
Summary
Precise control of the levels for individual cellular proteins is essential for homeostasis and is achieved in part by the activity of a class of enzymes called ubiquitin ligases, which mark proteins for degradation. The von Hippel-Lindau (VHL) tumour suppressor forms an ubiquitin ligase that regulates proteins involved in the oxygen response. VHL is mutated in the majority of renal clear-cell carcinoma (RCC). We have identified a new target of VHL, the retinoblastoma protein (pRb). Moreover, we have found that loss of VHL in RCC causes an accumulation of pRb, resulting in the suppression of genes that could promote death. This proposal will determine the biological effects of pRb stabilization in RCC as well as the mechanisms that govern the unexpected connection between these two important tumour-suppressor proteins.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
444306
Name
Russell Ryan
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Molecular & Cellular Biology of Cancer
Projecttitle
Identification of VHL-dependent dysfunction of the retinoblastoma protein in renal cancer RUNNING TITLE: Characterization of pRb dysfunction in RCC
Programtype2
Operating Grants
Orgnameinp2
University of Ottawa
Cihramount2
$875,926
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Kidney Cancer; Oxygen-Sensing; Tumour Suppressors
Abstract
Precise control of the levels for individual cellular proteins is essential for homeostasis and is achieved in part by the activity of a class of enzymes called ubiquitin ligases, which mark proteins for degradation. The von Hippel-Lindau (VHL) tumour suppressor forms an ubiquitin ligase that regulates proteins involved in the oxygen response. VHL is mutated in the majority of renal clear-cell carcinoma (RCC). We have identified a new target of VHL, the retinoblastoma protein (pRb). Moreover, we have found that loss of VHL in RCC causes an accumulation of pRb, resulting in the suppression of genes that could promote death. This proposal will determine the biological effects of pRb stabilization in RCC as well as the mechanisms that govern the unexpected connection between these two important tumour-suppressor proteins.
Competitiondate
202104
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Russell, Ryan
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $875,926~ $0~
