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Grant: Operating Grant

Research Institute of the McGill University Health Centre

$573,856.00

Structural and functional neuroimaging, cognitive testing and postural stability assessment in children with mild traumatic brain injury

FY 2010-11

Summary
Over the last decade, awareness of the problems associated with mild traumatic brain injury (MTBI) in children has grown significantly. Although cognitive, behavioural and physical symptoms are reported by the families as well as by the children with mTBI, the results of conventional clinical tests are often negative making their sensitivity questionable. Clinical studies by our team have revealed that children can present with balance and visual perceptual deficits after a MTBI in addition to decreased self confidence at the time of returning to regular activities. Attempts to link these deficits to the results of the imaging examinations have up to now failed. In the first part of the present study, we will ask children with and without a MTBI to perform memory tasks while undergoing a functional magnetic resonance imaging test. This procedure will allow us to examine each subject's brain in activity while they are performing the task. We will also evaluate balance, overall cognitive abilities and variables pertaining to the trauma (severity scores, duration of loss of consciousness, duration of post-traumatic amnesia, characteristics of the head injury sustained). In the second part of the study, one month later, we will reexamine brain function of those children who did not recover from the MTBI with the aim to compare to those who recuperated. We will then be able to compare each profile to its own obtained immediately after the trauma. We believe this study has the potential to provide a powerful diagnostic and prognostic method to document the degree of disability and recovery in children having sustained a mild head injury.
Program
Operating Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database

As published

Id
211130
Name
Ptito Alain
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Clinical
Prcname2
Social & Developmental Aspects of Children's & Youth's Health
Projecttitle
Structural and functional neuroimaging, cognitive testing and postural stability assessment in children with mild traumatic brain injury
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$573,856
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Balance And Posture; Child Health; Diffusion Tensor Imaging; Functional Magnetic Resonance Imaging; Mild Traumatic Brain Injury; Neuropsychological Testing; Paediatric; Post Concussion Symptoms; Recovery; Voxel-Based Morphometry
Abstract
Over the last decade, awareness of the problems associated with mild traumatic brain injury (MTBI) in children has grown significantly. Although cognitive, behavioural and physical symptoms are reported by the families as well as by the children with mTBI, the results of conventional clinical tests are often negative making their sensitivity questionable. Clinical studies by our team have revealed that children can present with balance and visual perceptual deficits after a MTBI in addition to decreased self confidence at the time of returning to regular activities. Attempts to link these deficits to the results of the imaging examinations have up to now failed. In the first part of the present study, we will ask children with and without a MTBI to perform memory tasks while undergoing a functional magnetic resonance imaging test. This procedure will allow us to examine each subject's brain in activity while they are performing the task. We will also evaluate balance, overall cognitive abilities and variables pertaining to the trauma (severity scores, duration of loss of consciousness, duration of post-traumatic amnesia, characteristics of the head injury sustained). In the second part of the study, one month later, we will reexamine brain function of those children who did not recover from the MTBI with the aim to compare to those who recuperated. We will then be able to compare each profile to its own obtained immediately after the trauma. We believe this study has the potential to provide a powerful diagnostic and prognostic method to document the degree of disability and recovery in children having sustained a mild head injury.
Competitiondate
201009
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Ptito, Alain; Gagnon, Isabelle; Petrides, Michael
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $573,856~ $0~