Grant: Operating Grant
Research Institute of the McGill University Health Centre
$576,454.00
Integrated proteomics and genomics approach to characterize a risk locus for type 2 diabetes
FY 2011-12
Summary
Adult-onset diabetes frequently occurs in family members as a result of inherited changes in the sequence of their genes. We have discovered a number of changes in DNA can make people more prone to developing diabetes. None of these genetic changes are sufficient to cause diabetes by themselves; rather, they work together to impair specific functions of cells in the body that leads to disease. In the current project, we will use state-of-the-art technologies to study a large number of proteins that are affected by a genetic risk locus on chromosome 6 to determine how it affects the pancreas's ability to make adequate amounts of insulin.
Department
Program
Operating Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
254302
Name
Sladek Robert G
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genetics
Projecttitle
Integrated proteomics and genomics approach to characterize a risk locus for type 2 diabetes
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$576,454
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Beta Cell Physiology; Common Genetic Variants; Diabetes Genetics; Diabetes Pathogenesis; Functional Genomics; Gene Expression; Protein Networks; Proteomics; Rare Genetic Variants; Transcription Factors
Abstract
Adult-onset diabetes frequently occurs in family members as a result of inherited changes in the sequence of their genes. We have discovered a number of changes in DNA can make people more prone to developing diabetes. None of these genetic changes are sufficient to cause diabetes by themselves; rather, they work together to impair specific functions of cells in the body that leads to disease. In the current project, we will use state-of-the-art technologies to study a large number of proteins that are affected by a genetic risk locus on chromosome 6 to determine how it affects the pancreas's ability to make adequate amounts of insulin.
Competitiondate
201203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sladek, Robert G
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $576,454~ $0~
