Grant: Operating Grant
Research Institute of the McGill University Health Centre
$872,210.00
Dissection of the molecular mechanism controlling the establishment of neuronal circuitry during development
FY 2010-11
Summary
One key issue in treating nerve injuries is how to restore the appropriate neuronal circuitry for functional recovery. In this application, I propose to utilize fruitfly as a model system to study the molecular mechanism by which neuronal circuitry is initially established during development. We will investigate the mechanism by which two evolutionarily conserved genes Semaphorin and Turtle regulate the assembly of neuronal circuitry in the developing nervous system. By taking a combination of molecular and genetic approaches, we will determine how these genes interact with other genes to facilitate the wiring of neural networks. The proposed research will provide invaluable clues to the development of new therapeutical approaches to treat neurological diseases and nerve injuries in humans.
Department
Program
Operating Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
210890
Name
Rao Yong
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
Dissection of the molecular mechanism controlling the establishment of neuronal circuitry during development
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$872,210
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Axon Guidance; Cell Biology; Cell Culture; Drosophila Genetics; Immunohistochemistry; Molecular Biology; Tiling And Self-Avoidance
Abstract
One key issue in treating nerve injuries is how to restore the appropriate neuronal circuitry for functional recovery. In this application, I propose to utilize fruitfly as a model system to study the molecular mechanism by which neuronal circuitry is initially established during development. We will investigate the mechanism by which two evolutionarily conserved genes Semaphorin and Turtle regulate the assembly of neuronal circuitry in the developing nervous system. By taking a combination of molecular and genetic approaches, we will determine how these genes interact with other genes to facilitate the wiring of neural networks. The proposed research will provide invaluable clues to the development of new therapeutical approaches to treat neurological diseases and nerve injuries in humans.
Competitiondate
201009
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Rao, Yong
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $872,210~ $0~
