Grant: Project Grant
University of Victoria (British Columbia)
$1,040,400.00
Molecular insights into mucin degradation by host-adapted microbes.
FY 2024-25
Summary
Mucous layers of the human body provide a physical barrier that protects tissues from
challenge by disease causing microorganisms. These sticky layers are formed mainly by gelforming
proteins that are highly modified with carbohydrates that are attached the protein.
These so-called mucins are key to the protective role of the mucous layer. Bacteria that
encounter mucous layer to colonize them or during infection use specialized enzymes to
breakdown the mucin. This research aims to understand how these enzymes, which we call
O-glycopeptidases, destroy mucins and thereby aid the bacteria to establish residence and/or
disease in humans.
Department
Program
Project Grant
Location
British Columbia, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
522138
Name
Boraston Alisdair B
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - A
Projecttitle
Molecular insights into mucin degradation by host-adapted microbes.
Programtype2
Operating Grants
Orgnameinp2
University of Victoria (British Columbia)
Cihramount2
$1,040,400
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Enzymology; Glycobiology; O-Glycosylation; Peptidase; Structural Biology
Abstract
Mucous layers of the human body provide a physical barrier that protects tissues from
challenge by disease causing microorganisms. These sticky layers are formed mainly by gelforming
proteins that are highly modified with carbohydrates that are attached the protein.
These so-called mucins are key to the protective role of the mucous layer. Bacteria that
encounter mucous layer to colonize them or during infection use specialized enzymes to
breakdown the mucin. This research aims to understand how these enzymes, which we call
O-glycopeptidases, destroy mucins and thereby aid the bacteria to establish residence and/or
disease in humans.
Competitiondate
202503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Boraston, Alisdair B; Wakarchuk, Warren W
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,040,400~ $0~
