Grant: Project Grant
Institut de recherches cliniques de Montréal
$826,200.00
Pioneer activity of the Hox13 transcription factors in developing limbs
FY 2018-19
Summary
Genes of the Hox family are critical for the proper development of the embryo as illustrated by the numerous defects associated with mutations in Hox genes. It is therefore critical to understand how these genes function. Based on our previous work and preliminary data, we have evidence suggesting that the Hox13 genes have a pioneer activity, i.e. they act as a switch to change cell fate. We propose to characterize this function of Hox13 and its relevance for proper development of the foetus. Our work should help understanding the molecular defects associated with the Hand-foot-genital syndrome, due to the mutation of the Hoxa13 gene.
Department
Program
Project Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
388984
Name
Kmita Marie T
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Developmental Biology
Projecttitle
Pioneer activity of the Hox13 transcription factors in developing limbs
Programtype2
Operating Grants
Orgnameinp2
Institut de recherches cliniques de Montréal
Cihramount2
$826,200
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Chromatin Remodellers; Enhancers; Evolution; Hox Genes; Limb Development; Transcriptional Regulation
Abstract
Genes of the Hox family are critical for the proper development of the embryo as illustrated by the numerous defects associated with mutations in Hox genes. It is therefore critical to understand how these genes function. Based on our previous work and preliminary data, we have evidence suggesting that the Hox13 genes have a pioneer activity, i.e. they act as a switch to change cell fate. We propose to characterize this function of Hox13 and its relevance for proper development of the foetus. Our work should help understanding the molecular defects associated with the Hand-foot-genital syndrome, due to the mutation of the Hoxa13 gene.
Competitiondate
201809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Kmita, Marie T
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $826,200~ $0~
