Grant: Proof of Principle Program - Phase I
University of Manitoba
$137,617.00
Preclinical development of glycerophosphocarbamates as prostate-selective anticancer drugs
FY 2009-10
Summary
We have discovered that some fat-like molecules that we have made in our lab are able to kill cancer cells. Remarkably they kill prostate cancer cells more readily than cancer cells from other tissues. In this proosal we want to find out which of the compounds we have is best able to stop the growth of human prostate tumors that have been placed in mice. This will allow us to detrmine the one that is best for further development into a clinically useful drug. We also want to discover how these compounds are able to affect prostate cancer cells much more than other cells since this will allow us to understand how we may be able to make compounds to treat prostate cancer with little side efects.
Department
Program
Proof of Principle Program - Phase I
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
184831
Name
Arthur Gilbert
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Proof of Principle
Projecttitle
Preclinical development of glycerophosphocarbamates as prostate-selective anticancer drugs
Programtype2
Operating Grants
Orgnameinp2
University of Manitoba
Cihramount2
$137,617
Cihrequipment2
$0
Programname2
Proof of Principle Program - Phase I
Keyworddelim
Anti Cancer Drugs; Cell Culture; Chemical Synthesis; Ether Lipids; Phosphocarbamates; Prostate Cancer; Uptake And Metabolic Studies; Xenograft Prostate Cancer
Abstract
We have discovered that some fat-like molecules that we have made in our lab are able to kill cancer cells. Remarkably they kill prostate cancer cells more readily than cancer cells from other tissues. In this proosal we want to find out which of the compounds we have is best able to stop the growth of human prostate tumors that have been placed in mice. This will allow us to detrmine the one that is best for further development into a clinically useful drug. We also want to discover how these compounds are able to affect prostate cancer cells much more than other cells since this will allow us to understand how we may be able to make compounds to treat prostate cancer with little side efects.
Competitiondate
200904
Approvedterm2
1 yr 0 mth
Pinamesdelim
Arthur, Gilbert
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $137,617~ $0~
