Grant: CIHR New Investigator
University of Toronto
$300,000.00
Determining function of uncharacterized enzymes by quantitative metabolic profiling using high resolution mass spectrometry
FY 2011-12
Summary
Organisms take up nutrients and break them down to release the energy necessary for cellular maintenance or chemically transform them to make the building blocks necessary for growth. Mass spectrometry allows close examination of the chemicals within cells. This project will identify previously unknown metabolic pathways within cells. Knowledge of these pathways is necessary to understand how cells use nutrients. In addition, discovery of new pathways can permit the development of new small molecule drugs to regulate cellular growth.
Department
Program
CIHR New Investigator
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
241222
Name
Caudy Amy A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
New Investigators A
Projecttitle
Determining function of uncharacterized enzymes by quantitative metabolic profiling using high resolution mass spectrometry
Programtype2
Salary Programs
Orgnameinp2
University of Toronto
Cihramount2
$300,000
Cihrequipment2
$0
Programname2
CIHR New Investigator
Keyworddelim
Biochemical Networks; Enzyme Function; Glycolysis; Mass Spectrometry; Metabolomics; Pentose Phosphate Pathway; Redox Stress; Riboneogenesis; Sedoheptulose Bisphosphate; Yeast Prototroph
Abstract
Organisms take up nutrients and break them down to release the energy necessary for cellular maintenance or chemically transform them to make the building blocks necessary for growth. Mass spectrometry allows close examination of the chemicals within cells. This project will identify previously unknown metabolic pathways within cells. Knowledge of these pathways is necessary to understand how cells use nutrients. In addition, discovery of new pathways can permit the development of new small molecule drugs to regulate cellular growth.
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Caudy, Amy A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $300,000~ $0~
