Grant: Proof of Principle Program - Phase I

In previous work we have synthesized new molecules that can mediate effects on two types of proteins (estrogen receptors),called ERalpha and ER beta, that receive estrogenic signals. The ERalpha can promote breast cancer growth but it is also the receptor in the brain that controls temperature control (hot flashes). In contrast the ERbeta antagonizes the cancer promoting effects of the ERalpha. This proposal will test the safety and efficacy of novel drugs that preferentially activate with the ERbeta receptor to both inhibit the breast cancer-associated effects of estrogen while retaining sufficient ERalpha activity to prevent hot flashes.