Grant: Project Grant
McGill University
$585,225.00
MicroRNA cooperativity in mRNA translation repression and deadenylation, from genome edition to single-molecule imaging
FY 2016-17
Summary
Recently, an important new class of molecules influencing cell behavior was discovered: the microRNAs. About one thousand of these little nucleic acid regulators are at work in human cells, and they have been implicated in almost every biological process, but also in numerous diseases including cancer. MicroRNAs act as repressors of genes by directly binding to a portion of the messengers of genes (mRNAs), termed the 3 prime untranslated region (3'UTR). MicroRNAs interact with RNA-binding proteins (RBPs) and 3'UTRs to finely tune the expression of genes. Better understanding how microRNA interact with mRNAs and with RBPs will allow to discern on the biologically important microRNA-binding sites in the genome from weak or non-functional ones. Hence, this project offers much promise in grasping the impact of microRNAs and RBPs in important biological processes, and their roles in diseases.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
358673
Name
Duchaine Thomas
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
MicroRNA cooperativity in mRNA translation repression and deadenylation, from genome edition to single-molecule imaging
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$585,225
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
3' Untranslated Region; Argonaute; C. Elegans; Cell-Free Assays; Deadenylase; Microrna; Post-Transcriptional Gene Regulation; Rna Processing; Rna-Binding Proteins; Single-Molecule Imaging
Abstract
Recently, an important new class of molecules influencing cell behavior was discovered: the microRNAs. About one thousand of these little nucleic acid regulators are at work in human cells, and they have been implicated in almost every biological process, but also in numerous diseases including cancer. MicroRNAs act as repressors of genes by directly binding to a portion of the messengers of genes (mRNAs), termed the 3 prime untranslated region (3'UTR). MicroRNAs interact with RNA-binding proteins (RBPs) and 3'UTRs to finely tune the expression of genes. Better understanding how microRNA interact with mRNAs and with RBPs will allow to discern on the biologically important microRNA-binding sites in the genome from weak or non-functional ones. Hence, this project offers much promise in grasping the impact of microRNAs and RBPs in important biological processes, and their roles in diseases.
Competitiondate
201610
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Duchaine, Thomas
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $585,225~ $0~
