Grant: Operating Grant

Antibiotic resistance has reached crisis proportions. It is the product of natural selection and is inexorable, yet the crippling effect of drug resistant infectious diseases can be mitigated by continuous development of novel antibacterial medicines. Recognizing the need for new therapies with novel mechanisms, we seek to better understand the most basic elements of poorly understood but core physiology in bacteria to reveal chinks in the armor of important pathogens. In the work proposed here we hope to break fresh ground in the discovery of new probes of bacterial metabolism with the expectation that this work will lead to novel leads for new antibiotics.