Grant: CIHR-ICRH Travel Awards - General pool
Centre hospitalier de l'Université de Montréal (CHUM)
$1,250.00
Renal Tubule-Specific NRF2 Deletion Down-Regulates SGLT2 and Angiotensinogen Expression and Ameliorates GFR and Kidney Injury in Akita Mice
FY 2023-24
Summary
The study aimed to investigate the role of NRF2, a protein associated with diabetes, in the progression of diabetic kidney disease (DKD). The researchers examined the effects of removing NRF2 specifically from the renal tubules in Akita mice, a model of type 1 diabetes. They found that deleting NRF2 in the renal tubules improved blood glucose levels and kidney health in these mice. The improvement was attributed to the reduction of certain proteins involved in kidney damage. The study suggests that targeting NRF2 in the kidneys could be a potential treatment strategy for DKD.
Department
Program
CIHR-ICRH Travel Awards - General pool
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
495599
Name
Su Ke
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Prcname2
Special Cases
Projecttitle
Renal Tubule-Specific NRF2 Deletion Down-Regulates SGLT2 and Angiotensinogen Expression and Ameliorates GFR and Kidney Injury in Akita Mice
Programtype2
Undefined
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$1,250
Cihrequipment2
$0
Programname2
CIHR-ICRH Travel Awards - General pool
Keyworddelim
Diabetic Kidney Disease
Abstract
The study aimed to investigate the role of NRF2, a protein associated with diabetes, in the progression of diabetic kidney disease (DKD). The researchers examined the effects of removing NRF2 specifically from the renal tubules in Akita mice, a model of type 1 diabetes. They found that deleting NRF2 in the renal tubules improved blood glucose levels and kidney health in these mice. The improvement was attributed to the reduction of certain proteins involved in kidney damage. The study suggests that targeting NRF2 in the kidneys could be a potential treatment strategy for DKD.
Competitiondate
202309
Approvedterm2
1 yr 0 mth
Pinamesdelim
Su, Ke
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $1,250~ $0~
