Grant: Alliance Grants

This research proposal outlines a groundbreaking international collaboration aimed at developing new DNA aptamers for glucagon-like peptide-1 (GLP-1) and an aptamer-based biosensor for this peptide in partnership with Prof. Kazunori Ikebukuro from the Tokyo University of Agriculture & Technology, Japan. The primary goal is to leverage these advancements for improved diagnostics of conditions impacted by GLP-1, notably in the realms of diabetes and obesity management. This collaboration stands to significantly enhance the diagnostic and therapeutic landscape for these conditions by providing new tools for drug discovery and disease management. The proposed collaboration promises to address critical scientific questions within bioanalytical and nucleic acid chemistry, as well as broader natural sciences and engineering (NSE) disciplines. It is poised to revolutionize methods for the prevention, diagnosis, prognosis, monitoring, and treatment of autoimmune diseases, particularly diabetes and obesity. This will be achieved through refined aptamer selection, screening, and developing advanced biosensors, thus contributing to improved clinical outcomes. The collaboration with Prof. Ikebukuro brings a multidisciplinary approach and access to advanced technologies, further elevating the project's scope and depth. The Berezovski lab at the University of Ottawa will play a crucial role in aptamer selection and characterization, leveraging its state-of-the-art facilities and expertise in bioanalytical chemistry. Additionally, the project includes a comprehensive training plan for research trainees, encompassing workshops and transferrable skills courses to enhance technical and professional capabilities. This approach not only aims to foster the next generation of researchers but also emphasizes equity, diversity, and inclusion (EDI) in all aspects of the research environment and team composition.