Grant: Alliance Grants

At TMU researchers have developed a method to synthesize unique nanoparticle networks through Mega Hertz femtosecond laser ablation of solids. The nanoparticle networks have a unique porous three-dimensional (3D) interweaved nanowire-frame structure. Investigation has shown that the three-dimensionality significantly improves light absorptance, increase signal level for biosensing and imaging. Synthesis and processing methods affect the material chemical composition, crystallinity, and structure. Minor changes to the synthesis technique can significantly affect produced nanoparticles' structural and morphological properties and capacity for intended applications. In this research Laser ablation synthesis in solution (LASiS) will be adopted to further enhance the synthesis capability of the ultrafast laser process. In the last decade, LASiS has been introduce as a unique and efficient technique that could substitute chemical and other physical processes for developing ultrapure, homogenous, and non-toxic nanoparticle. LASiS is a relatively simple process that doesn't require complicated setups or intricate reaction conditions. The lack of surfactants or chemical additives makes the synthesis process less complex, scalable and clean, making it particularly suitable for biomedical applications. The main goal of this collaboration is to achieve large-scale production of nanoparticles with precise control over their size, shape, and composition using a top-down LASiS technique. The effectiveness of nanoparticles synthesized through LASiS for applications in optical imaging and biosensing (Bio-imse NPs) in biomedicine will be evaluated.