Grant: Operating Grant
University of Alberta
$768,687.00
Dissecting the signalling functions of polycomb-mediated ubiquitylation in DNA double-strand break repair
FY 2011-12
Summary
The presence of stem cells within human tumours and their increased resistance to therapies are thought to be a major reason why some patients fail therapy. We have found that a group of proteins that are essential for maintaining stem cells are also involved in the repair of DNA double-strand breaks. This may provide an important link and expose an "Achilles heel" of tumours. That is, if we are able to disrupt the function of these proteins, we may be able to sensitize these cancer stem cells such that they are as sensitive to therapy as the remaining tumour. In order to pursue this goal, we are trying to build a base of knowledge around our original discovery that will help us design strategies to exploit our finding.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
239080
Name
Hendzel Michael J
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Molecular & Cellular Biology of Cancer
Projecttitle
Dissecting the signalling functions of polycomb-mediated ubiquitylation in DNA double-strand break repair
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$768,687
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Bap1; Cancer Stem Cell; Chromatin; Dna Double-Strand Breaks; Polycomb; Radiation Therapy; Ubiquitylation
Abstract
The presence of stem cells within human tumours and their increased resistance to therapies are thought to be a major reason why some patients fail therapy. We have found that a group of proteins that are essential for maintaining stem cells are also involved in the repair of DNA double-strand breaks. This may provide an important link and expose an "Achilles heel" of tumours. That is, if we are able to disrupt the function of these proteins, we may be able to sensitize these cancer stem cells such that they are as sensitive to therapy as the remaining tumour. In order to pursue this goal, we are trying to build a base of knowledge around our original discovery that will help us design strategies to exploit our finding.
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Hendzel, Michael J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $768,687~ $0~
