Grant: Operating Grant
University of British Columbia
$720,495.00
The role of innate phagocytic function in control of inflammation from infection or injury
FY 2009-10
Summary
White blood cells play a critical role in control of inflammation. The mechanisms in humans can be best understood by the study of their cells as they try to control inflammation after infection or injury. I propose to continue my CIHR-funded research by extending studies done during the past five years. I have been studying the interaction of cells which ingest bacteria (phagocytes) and bacteria to better understand the reasons why the system can go awry and inflammation can be damaging to the human host. I propose to study the interaction of phagocytes with two different types of bacteria (one which causes infection in cystic fibrosis and one which causes tuberculosis). I will also study people in whom there is loss of control of inflammation. By studying such "experiments of nature," a clearer understanding of the control mechanisms of inflammation should be uncovered.
Department
Program
Operating Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
189211
Name
Speert David P
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Microbiology & Infectious Diseases
Projecttitle
The role of innate phagocytic function in control of inflammation from infection or injury
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$720,495
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Apoptosis; Dendritic Cell; Innate Immunity; Macrophage; Neutrophil; Phagocytosis
Abstract
White blood cells play a critical role in control of inflammation. The mechanisms in humans can be best understood by the study of their cells as they try to control inflammation after infection or injury. I propose to continue my CIHR-funded research by extending studies done during the past five years. I have been studying the interaction of cells which ingest bacteria (phagocytes) and bacteria to better understand the reasons why the system can go awry and inflammation can be damaging to the human host. I propose to study the interaction of phagocytes with two different types of bacteria (one which causes infection in cystic fibrosis and one which causes tuberculosis). I will also study people in whom there is loss of control of inflammation. By studying such "experiments of nature," a clearer understanding of the control mechanisms of inflammation should be uncovered.
Competitiondate
200909
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Speert, David P
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $720,495~ $0~
