Grant: Operating Grant

Insulin is a hormone produced by pancreas in our body. It controls the levels of sugar in blood and its utilization by other tissues. Either a lack of enough insulin in the blood or reasons that interfere with its function, cause diabetes. In order to understand how our body produces and releases insulin under different dietary conditions and the regulation of this process, we are proposing the present research. Specifically, the primary goal of our proposal is to identify both the positive and negative signals within the pancreatic beta cell that mediate the link between the metabolism of glucose and fats and the release of insulin. A better knowledge of the molecular basis of the insulin secretion process is necessary to develop novel therapeutics against diabetes that work efficiently and without any unwanted side effects.