Grant: Project Grant
Université de Sherbrooke
$1,082,476.00
The role of Interleukin-15 signaling in the pathogenesis of liver fibrosis
FY 2019-20
Summary
Liver cancer ranks as the fifth most common cancer and the third leading cause of cancer-related death. Most liver cancer patients die within one year due to lack of effective treatment. Liver cancer invariably develops following repeated and sustained liver injury caused by hepatitis viruses, alcohol abuse, and more importantly, obesity. The chronic inflammatory condition caused by these agents and conditions induces excess production of fibrous material that promotes the development of liver cancer. Research in our laboratory indicates that a pro-inflammatory cytokine called IL-15 plays a key pathogenic role in the development of liver fibrosis. The goal of this research project is to understand how IL-15 promotes the production of fibrous tissue. This knowledge could lead to identification of new therapeutic targets to treat liver fibrosis, and in doing so, to treat liver cancer.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
419372
Name
Ramanathan Sheela
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Cell Biology - Disease
Projecttitle
The role of Interleukin-15 signaling in the pathogenesis of liver fibrosis
Programtype2
Operating Grants
Orgnameinp2
Université de Sherbrooke
Cihramount2
$1,082,476
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Anti-Il-15 Therapeutics; Carbon Tetrachloride; Choline-Deficient High Fat Diet; Hepatic Stellate Cells; Interleukin-15; Liver Fibrosis; Pre-Clinical Models
Abstract
Liver cancer ranks as the fifth most common cancer and the third leading cause of cancer-related death. Most liver cancer patients die within one year due to lack of effective treatment. Liver cancer invariably develops following repeated and sustained liver injury caused by hepatitis viruses, alcohol abuse, and more importantly, obesity. The chronic inflammatory condition caused by these agents and conditions induces excess production of fibrous material that promotes the development of liver cancer. Research in our laboratory indicates that a pro-inflammatory cytokine called IL-15 plays a key pathogenic role in the development of liver fibrosis. The goal of this research project is to understand how IL-15 promotes the production of fibrous tissue. This knowledge could lead to identification of new therapeutic targets to treat liver fibrosis, and in doing so, to treat liver cancer.
Competitiondate
202003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Ramanathan, Sheela
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,082,476~ $0~
