Grant: Operating Grant
Université Laval
$647,220.00
Molecular basis for vascular remodeling in pulmonary arterial hypertension
FY 2011-12
Summary
Pulmonary hypertension is a disease of the lung blood vessels characterized by a sustained proliferation of the cells composing the lung blood vessel wall. This proliferation will decrease blood perfusion and thus blood oxygenation. Despite new therapeutic this disease remain lethal with 30% of mortality within 3 years after diagnostic.
We propose to study the role of miR-204 in the proliferation of the cell within pulmonary vessels.
Preliminary evidence suggest that the downregulation of miR204 is implicated in the cell proliferation and thus could be of a great therapeutic interest.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
237010
Name
Bonnet Sébastien
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Cardiovascular System - C: Vascular System
Projecttitle
Molecular basis for vascular remodeling in pulmonary arterial hypertension
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$647,220
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Micrornas; Pulmonary Hypertension
Abstract
Pulmonary hypertension is a disease of the lung blood vessels characterized by a sustained proliferation of the cells composing the lung blood vessel wall. This proliferation will decrease blood perfusion and thus blood oxygenation. Despite new therapeutic this disease remain lethal with 30% of mortality within 3 years after diagnostic.
We propose to study the role of miR-204 in the proliferation of the cell within pulmonary vessels.
Preliminary evidence suggest that the downregulation of miR204 is implicated in the cell proliferation and thus could be of a great therapeutic interest.
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Bonnet, Sébastien
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $647,220~ $0~
