Grant: Operating Grant
Research Institute of the McGill University Health Centre
$1,023,674.00
A randomized trial to compare effectiveness of 4 months Rifampin (4 RIF) with 9 months Isoniazid (9 INH) in the prevention of active TB in children: The P4v9 Trial
FY 2010-11
Summary
Tuberculosis (TB) is spread by airborne transmission from adults with active contagious TB to children, especially those living in the same household. Once children are exposed and infected they are at very high risk to develop active TB - which can be lethal if not detected and treated promptly. This makes it very important to detect TB infection as soon as possible, and treat this while it is still latent or dormant. Current therapy for latent TB infection is 9 months of Isoniazid; this is very effective if taken properly but because treatment is so long many children do not finish this. 4 months Rifampin is a recommended alternative. In adults this has been shown to be safer with much better completion. However the effectiveness of this treatment is unclear, and is being studied in an ongoing study. We plan to compare the safety as well as the acceptability and effectiveness of 4 months Rifampin with 9 months Isoniazid (standard treatment) in children in several sites in Canada and other countries.
Department
Program
Operating Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
210714
Name
Menzies Richard
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Population and Public Health
Theme2
Clinical
Prcname2
Randomized Controlled Trials
Projecttitle
A randomized trial to compare effectiveness of 4 months Rifampin (4 RIF) with 9 months Isoniazid (9 INH) in the prevention of active TB in children: The P4v9 Trial
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$1,023,674
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Child Health; Global Health; Latent Tb Infection; Randomized Trail; Tuberculosis Prevention; Tuberculosis Treatment
Abstract
Tuberculosis (TB) is spread by airborne transmission from adults with active contagious TB to children, especially those living in the same household. Once children are exposed and infected they are at very high risk to develop active TB - which can be lethal if not detected and treated promptly. This makes it very important to detect TB infection as soon as possible, and treat this while it is still latent or dormant. Current therapy for latent TB infection is 9 months of Isoniazid; this is very effective if taken properly but because treatment is so long many children do not finish this. 4 months Rifampin is a recommended alternative. In adults this has been shown to be safer with much better completion. However the effectiveness of this treatment is unclear, and is being studied in an ongoing study. We plan to compare the safety as well as the acceptability and effectiveness of 4 months Rifampin with 9 months Isoniazid (standard treatment) in children in several sites in Canada and other countries.
Competitiondate
201009
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Menzies, Richard
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,023,674~ $0~
