Grant: Project Grant - PA: Infection and Immunity (Early Career Research Support)
University of Toronto
$300,000.00
Dissecting the roles of sialoglycans in T cell activation, phenotype, and function
FY 2022-23
Summary
The proposed research aims to better understand the mechanisms that govern a newly discovered level of immune modulation. We have recently shown that specific carbohydrates that are presented on the surface of immune cells can tune inflammatory responses and potentially provide a handle for controlling how specific immune cells respond to stimuli. Our goals are to learn which specific carbohydrate structures are involved in this process, on which proteins they are presented, and if artificial manipulation of these structures can enable next-generation technologies for controlling immune cell activity.
Department
Program
Project Grant - PA: Infection and Immunity (Early Career Research Support)
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
483945
Name
Edgar Landon J
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology
Projecttitle
Dissecting the roles of sialoglycans in T cell activation, phenotype, and function
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$300,000
Cihrequipment2
$0
Programname2
Project Grant - PA: Infection and Immunity (Early Career Research Support)
Keyworddelim
Adaptive Immunity; Autoimmunity; Chemical Biology; Flow Cytometry; Glycobiology; Glycoengineering; Glycosylation; Immunophysiology; Sialic Acid; T Cells
Abstract
The proposed research aims to better understand the mechanisms that govern a newly discovered level of immune modulation. We have recently shown that specific carbohydrates that are presented on the surface of immune cells can tune inflammatory responses and potentially provide a handle for controlling how specific immune cells respond to stimuli. Our goals are to learn which specific carbohydrate structures are involved in this process, on which proteins they are presented, and if artificial manipulation of these structures can enable next-generation technologies for controlling immune cell activity.
Competitiondate
202303
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Edgar, Landon J
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $300,000~ $0~
