Grant: Doctoral Research Award - Hypertension Prevention
Centre hospitalier de l'Université de Montréal (CHUM)
$19,000.00
Functional genomic dissection of FAAH2 role in the sex-specific aspects of hypertension and obesity in French-Canadian families
FY 2008-09
Summary
Sexual dimorphism of blood pressure is well established. The sexual chromosome X, presents in one copy in men and two copies in women, is a potential candidate for this observation. Nevertheless, the mechanisms of the specific X chromosome implication in this effect are not clearly defined. We have detected a significant association between the fatty acid amide hydrolase 2 (FAAH2), an X chromosome gene, and blood pressure level. The main goal of the proposed research is to undertake a comprehensive genetic evaluation of FAAH2 to assess its causality. This project aims to identify the biological pathways between this gene and blood pressure regulation. We will verify the biological function of FAAH2 in the French Canadian population, a Czech cohort as well as rat models. Consequently, a better understanding of the sex-linked pattern in blood pressure determination may help to identify the real sex-specific therapeutic needs. This new knowledge will bring the possibility to improve the personalised aspect of medical management of hypertension in patients for whom current medications are not fully effective.
Department
Program
Doctoral Research Award - Hypertension Prevention
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
174545
Name
Noel Audrey
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Pfizer Canada Inc. (Quebec); Hypertension Canada (Markham, Ontario)
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Doctoral Research Awards - A
Projecttitle
Functional genomic dissection of FAAH2 role in the sex-specific aspects of hypertension and obesity in French-Canadian families
Programtype2
Studentship Programs
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$19,000
Cihrequipment2
$0
Programname2
Doctoral Research Award - Hypertension Prevention
Keyworddelim
Chromosome X; Functional Genomics; Genotype; Hypertension; Phenotype; Sex Specific Genetic Determinants; Single Nucleotide Polymorphism
Abstract
Sexual dimorphism of blood pressure is well established. The sexual chromosome X, presents in one copy in men and two copies in women, is a potential candidate for this observation. Nevertheless, the mechanisms of the specific X chromosome implication in this effect are not clearly defined. We have detected a significant association between the fatty acid amide hydrolase 2 (FAAH2), an X chromosome gene, and blood pressure level. The main goal of the proposed research is to undertake a comprehensive genetic evaluation of FAAH2 to assess its causality. This project aims to identify the biological pathways between this gene and blood pressure regulation. We will verify the biological function of FAAH2 in the French Canadian population, a Czech cohort as well as rat models. Consequently, a better understanding of the sex-linked pattern in blood pressure determination may help to identify the real sex-specific therapeutic needs. This new knowledge will bring the possibility to improve the personalised aspect of medical management of hypertension in patients for whom current medications are not fully effective.
Competitiondate
200810
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Noel, Audrey
Approvedterm
2 ans 0 mois
Cihrcontribution2
~ $19,000~ $0~
