Grant: Operating Grant
University of Toronto
$782,020.00
Molecular characterization of JMML
FY 2011-12
Summary
Juvenile myelomonocytic leukaemia (JMML) is a highly aggressive cancer that affects young children. There is no cure or effective treatment for JMML, which has an average survival rate of less than 20% past three years of diagnosis. In an effort to find effective treatment options for children with JMML, we uncovered a new molecular pathway critically involved in the development of JMML. This research proposal aims to provide insightful mechanistic understanding of why and how JMML develops with the supposition that learned lessons would aid in the development of new and effective therapeutic options for children with JMML.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
237850
Name
Ohh Michael
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Progression & Therapeutics
Projecttitle
Molecular characterization of JMML
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$782,020
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cbl; E3; Juvenile Myelomonocytic Leukaemia; Pharmacologic Inhibitor; Src; Ubiquitin
Abstract
Juvenile myelomonocytic leukaemia (JMML) is a highly aggressive cancer that affects young children. There is no cure or effective treatment for JMML, which has an average survival rate of less than 20% past three years of diagnosis. In an effort to find effective treatment options for children with JMML, we uncovered a new molecular pathway critically involved in the development of JMML. This research proposal aims to provide insightful mechanistic understanding of why and how JMML develops with the supposition that learned lessons would aid in the development of new and effective therapeutic options for children with JMML.
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Ohh, Michael
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $782,020~ $0~
