Grant: Operating Grant: Impact Grant : CEEHRC Phase II
McGill University
$600,000.00
Role of epigenetic modulation in breast cancer etiology and drug resistance.
FY 2017-18
Summary
Inactivation of tumor suppressors is associated with poor outcome in breast cancer, yet the underlying mechanisms are poorly understood. One underlying mechanism of gene repression is though modification of histones that influence chromatin structure. In this application, we will use both Genetic engineered mouse and patient derived xenograft models of human breast cancer to elucidate the role of enzyme complex known as PRC2 in repression of gene expression during tutor progression and acquisition of resistance to targeted therapies for breast cancer.
Department
Program
Operating Grant: Impact Grant : CEEHRC Phase II
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
368101
Name
Muller William J
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Operating Grant : Impact Grant: CEEHRC Phase II
Projecttitle
Role of epigenetic modulation in breast cancer etiology and drug resistance.
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$600,000
Cihrequipment2
$0
Programname2
Operating Grant: Impact Grant : CEEHRC Phase II
Keyworddelim
Breast Cancer; Epigenetic; Erbb2; Ezh2; Luminal B; Metastasis
Abstract
Inactivation of tumor suppressors is associated with poor outcome in breast cancer, yet the underlying mechanisms are poorly understood. One underlying mechanism of gene repression is though modification of histones that influence chromatin structure. In this application, we will use both Genetic engineered mouse and patient derived xenograft models of human breast cancer to elucidate the role of enzyme complex known as PRC2 in repression of gene expression during tutor progression and acquisition of resistance to targeted therapies for breast cancer.
Competitiondate
201708
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Muller, William J
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $600,000~ $0~
