Grant: CAG/CCFC/CIHR Summer Studentship for Research in Gastroenterology
University of Toronto
$3,000.00
Non-Alcoholic Fatty Liver Disease versus Healthy Controls: Differences in Fatty Acid Composition and Oxidative Stress
FY 2008-09
Summary
Non-alcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver damage ranging from simple steatosis to steatohepetitis (NASH), advanced fibrosis and cirrhosis. NAFLD affects 10-24% of the general population in various countries and NASH is the histologic diagnosis in 7-11% of patients undergoing liver biopsy in the US and Canada. While simple steatosis has a benign course, NASH can progress to fibrosis and cirrhosis in 15-50% of patients. NASH is associated with obesity, diabetes and hyperlipidemia and is becoming an important public health issue. The pathogenesis of NASH is poorly understood. The most recent hypothesis is that progression from simple steatosis to NASH and to advanced fibrosis results from insulin resistance leading to fat accumulation within hepatocytes. Along with obesity, insulin resistance, and oxidative stress have been associated with NASH. However, many individuals lack the typical risk factors. No one knows why some patients with steatosis have an indolent course while others developed NASH. Human data is scant on the role that nutrition may play regarding these factors. Our proposal may lead to future dietary recommendations and studies on antioxidant supplementation.
Department
Program
CAG/CCFC/CIHR Summer Studentship for Research in Gastroenterology
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
182300
Name
Piran Siavash
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Canadian Association of Gastroenterology (Oakville, Ontario)
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Clinical
Prcname2
CIHR - INMD - CAG (Canadian Association of Gastroenterology) Partnership
Projecttitle
Non-Alcoholic Fatty Liver Disease versus Healthy Controls: Differences in Fatty Acid Composition and Oxidative Stress
Programtype2
Summer Student Programs
Orgnameinp2
University of Toronto
Cihramount2
$3,000
Cihrequipment2
$0
Programname2
CAG/CCFC/CIHR Summer Studentship for Research in Gastroenterology
Keyworddelim
Anthropometry; Fatty Acid Composition; Insulin Resistance; Malnurition; Micronurition; Non-Alcoholic Fatty Liver Disease; Non-Alcoholic Steatohepatitis; Nuritional Intake; Nutrition; Oxidative Stress; Polyunsaturated Fatty Acids; Simple Steatosis
Abstract
Non-alcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver damage ranging from simple steatosis to steatohepetitis (NASH), advanced fibrosis and cirrhosis. NAFLD affects 10-24% of the general population in various countries and NASH is the histologic diagnosis in 7-11% of patients undergoing liver biopsy in the US and Canada. While simple steatosis has a benign course, NASH can progress to fibrosis and cirrhosis in 15-50% of patients. NASH is associated with obesity, diabetes and hyperlipidemia and is becoming an important public health issue. The pathogenesis of NASH is poorly understood. The most recent hypothesis is that progression from simple steatosis to NASH and to advanced fibrosis results from insulin resistance leading to fat accumulation within hepatocytes. Along with obesity, insulin resistance, and oxidative stress have been associated with NASH. However, many individuals lack the typical risk factors. No one knows why some patients with steatosis have an indolent course while others developed NASH. Human data is scant on the role that nutrition may play regarding these factors. Our proposal may lead to future dietary recommendations and studies on antioxidant supplementation.
Competitiondate
200902
Approvedterm2
0 yr 4 mths
Pinamesdelim
Piran, Siavash
Approvedterm
0 an 4 mois
Cihrcontribution2
Inst of Nutr Metabolism &Diab~ $3,000~ $0~
