Grant: Project Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$849,150.00
Neurovascular repair in glaucoma: novel mechanisms and therapeutic targets
FY 2023-24
Summary
Retinal ganglion cells, the neurons that die in glaucoma, require a constant source of blood supply to meet their oxygen and nutrient needs. We recently discovered interpericyte tunneling nanotubes (IPTNTs), highly specialized tube-like structures that regulate local blood flow in the retina. IPTNTs are damaged in glaucoma, which results in loss of vascular responses and blood supply. However, how IPTNTs are injured, and whether this can be reversed, is currently unknown. In this application, we propose to elucidate mechanisms that lead to IPTNT damage. We will use this knowledge to develop novel strategies to regenerate IPTNTs, improve blood flow and neuronal function, and restore vision in glaucoma.
Department
Program
Project Grant
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
499470
Name
Di Polo Adriana
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Cell Biology - Disease
Projecttitle
Neurovascular repair in glaucoma: novel mechanisms and therapeutic targets
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$849,150
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Cell Biology; Glaucoma; Mechanisms Of Disease; Retina; Retinal Ganglion Cell; Vascular Function
Abstract
Retinal ganglion cells, the neurons that die in glaucoma, require a constant source of blood supply to meet their oxygen and nutrient needs. We recently discovered interpericyte tunneling nanotubes (IPTNTs), highly specialized tube-like structures that regulate local blood flow in the retina. IPTNTs are damaged in glaucoma, which results in loss of vascular responses and blood supply. However, how IPTNTs are injured, and whether this can be reversed, is currently unknown. In this application, we propose to elucidate mechanisms that lead to IPTNT damage. We will use this knowledge to develop novel strategies to regenerate IPTNTs, improve blood flow and neuronal function, and restore vision in glaucoma.
Competitiondate
202403
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Di Polo, Adriana
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $849,150~ $0~
