Grant: Doctoral Research Award: Canada Graduate Scholarships

The ovary undergoes continuous tissue remodeling and wound repair through the progression of the reproductive cycle, notably during ovulation. Ovulation is a fundamental reproductive process that involves the rupture of the ovarian follicle and the release of the mature egg from the ovaries for fertilization to occur. The ovulatory event is associated with hallmark signs of inflammation which is crucial to maintain tissue health. However, sustained inflammation in the female reproductive system can give rise to several diseases such as ovarian cancer. In this research project, we aim to investigate how a subset of immune cells, known as innate lymphoid cells (ILCs) contribute to inflammation during ovulation. ILCs have been shown to have a critical role in maintaining tissue health in other organs such as the lungs and the small intestine, and likewise may contribute a similar role in the ovaries. The objective of this study is to understand and establish the role of ILCs in coordinating a healthy inflammatory response and maintaining tissue integrity during ovulation. Then, we aim to identify whether the dysregulation of these cells may lead to the development or progression of ovarian cancer. We anticipate that this study will lead to an improved understanding of mammalian ovulation by bridging the gap between the immune system and the female reproductive system. In doing so, we anticipate uncovering how the immune system regulates the reproductive functions of women's ovaries. Findings from the proposed study can guide future translational studies and help inform clinical management and predictions of Canadian women's reproductive health such as anovulation, infertility, and ovarian cancer risk.