Grant: Travel Awards - Institute Community Support
University of Saskatchewan
$1,500.00
Heme oxygenase and pancreatic regeneration
FY 2015-16
Summary
Diabetes mellitus is a metabolic disease affecting a large human population worldwide irrespective to age, gender, and ethnicity. Type-1 diabetes, which was initially known as childhood disease is now known to affect all ages of the population including adults. Type-1 diabetes is an autoimmune disease whereby T-cells destroy a large number of insulin producing beta cells causing insulin deficiency higher levels glucose. To date, type-1 diabetes has no cure, although it is managed mainly via insulin injections. In this proposal, a drug called hemin will be used to improve pancreatic beta cell viability in an animal model of type-1 diabetes and we will also study whether this drug can enhance beta cell regeneration in an injured pancreas. Thus, our proposal will unveil a novel role of hemin in pancreatic regeneration, which may open a new avenue for the treatment and management of type-1 diabetes in future.
Department
Program
Travel Awards - Institute Community Support
Recipient
Location
Saskatchewan, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
337318
Name
Mishra Manish
Region
Saskatchewan
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Institute of Nutrition, Metabolism and Diabetes
Projecttitle
Heme oxygenase and pancreatic regeneration
Programtype2
Undefined
Orgnameinp2
University of Saskatchewan
Cihramount2
$1,500
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Beta Cells; Diabetes; Heme Oxygenase; Immunoblotting; Immunohistochemistry; Inflammation; Insulin Signalling; Metabolism; Oxidative Stress; Regeneration
Abstract
Diabetes mellitus is a metabolic disease affecting a large human population worldwide irrespective to age, gender, and ethnicity. Type-1 diabetes, which was initially known as childhood disease is now known to affect all ages of the population including adults. Type-1 diabetes is an autoimmune disease whereby T-cells destroy a large number of insulin producing beta cells causing insulin deficiency higher levels glucose. To date, type-1 diabetes has no cure, although it is managed mainly via insulin injections. In this proposal, a drug called hemin will be used to improve pancreatic beta cell viability in an animal model of type-1 diabetes and we will also study whether this drug can enhance beta cell regeneration in an injured pancreas. Thus, our proposal will unveil a novel role of hemin in pancreatic regeneration, which may open a new avenue for the treatment and management of type-1 diabetes in future.
Competitiondate
201510
Approvedterm2
1 yr 0 mth
Pinamesdelim
Mishra, Manish
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Nutr Metabolism &Diab~ $1,500~ $0~
