Grant: Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador
Memorial University of Newfoundland
$206,555.00
Formate: a novel window into one-carbon metabolism
FY 2010-11
Summary
Impairments in one-carbon metabolism may result either from some vitamin deficiencies (Folate or Vitamin B12) or from genetic causes. These result in increased incidence of neural tube defects and are also associated with cognitive impairment in the elderly, as well as cardiovascular disease. We have found that formate (found in ant stings as formic acid) accumulates in the blood in these situations and may serve as an important indicator of ill health. It may be more than an indicator, it may play a causal role. We will investigate these questions in experimental animals and blood samples from large human populations.
Department
Program
Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador
Recipient
Location
Newfoundland and Labrador, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
234176
Name
Brosnan John (Sean) T
Region
Newfoundland and Labrador
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Newfoundland and Labrador Research & Development Corp.
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Nutrition, Food & Health
Projecttitle
Formate: a novel window into one-carbon metabolism
Programtype2
Operating Grants
Orgnameinp2
Memorial University of Newfoundland
Cihramount2
$206,555
Cihrequipment2
$0
Programname2
Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador
Keyworddelim
Folate; Formate; Homocysteine; Polymorphisms; Vitamin B12; Vitamin Deficiency
Abstract
Impairments in one-carbon metabolism may result either from some vitamin deficiencies (Folate or Vitamin B12) or from genetic causes. These result in increased incidence of neural tube defects and are also associated with cognitive impairment in the elderly, as well as cardiovascular disease. We have found that formate (found in ant stings as formic acid) accumulates in the blood in these situations and may serve as an important indicator of ill health. It may be more than an indicator, it may play a causal role. We will investigate these questions in experimental animals and blood samples from large human populations.
Competitiondate
201103
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Brosnan, John (Sean) T
Approvedterm
3 ans 0 mois
Cihrcontribution2
SPIR~ $206,555~ $0~
