Grant: CIHR-ICRH Travel Awards - General pool
University of Ottawa
$1,500.00
Hyperlipidemia-induced Hematopoiesis is Repressed by MLKL in Endothelial Cells of the Splenic Niche
FY 2022-23
Summary
Atherosclerosis is a chronic complication of cardiovascular disease and is characterized by increases in circulating lipid levels, as well as chronic low-grade inflammation, which together exacerbate the development of lipid- and immune-rich plaques that deposit within the arterial wall. My work here describes the influence of these elevated lipids on dysregulating splenic endothelial cells to in turn promote the production of immune cells from the spleen that ultimately home to and participate in plaque development.
Department
Program
CIHR-ICRH Travel Awards - General pool
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
481044
Name
Rasheed Adil
Region
Ontario
Country
Canada
Orgtype
Research Institution; Institution Paid
Prcname2
Special Cases
Projecttitle
Hyperlipidemia-induced Hematopoiesis is Repressed by MLKL in Endothelial Cells of the Splenic Niche
Programtype2
Undefined
Orgnameinp2
University of Ottawa
Cihramount2
$1,500
Cihrequipment2
$0
Programname2
CIHR-ICRH Travel Awards - General pool
Keyworddelim
Hematopoiesis; Hyperlipidemia; Mlkk; Splenic Niche
Abstract
Atherosclerosis is a chronic complication of cardiovascular disease and is characterized by increases in circulating lipid levels, as well as chronic low-grade inflammation, which together exacerbate the development of lipid- and immune-rich plaques that deposit within the arterial wall. My work here describes the influence of these elevated lipids on dysregulating splenic endothelial cells to in turn promote the production of immune cells from the spleen that ultimately home to and participate in plaque development.
Competitiondate
202301
Approvedterm2
1 yr 0 mth
Pinamesdelim
Rasheed, Adil
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $1,500~ $0~
