Grant: Strategic Projects - Group
University of British Columbia
$112,690.00
MEMS-based drug delivery devices
FY 2007-08
Summary
Localized, controlled drug release has gained clinical relevance in treating proliferative diseases in the past decade. The rapidly proliferating cells can keep systemic antiproliferative drugs from entering the capillary networks in the tissue. As a result, many proliferative diseases, such as diabetic retinopathy do not respond well to systemic drug administration. State-of-the-artpolymeric-based drug delivery systems can be intraocularly injected to provide localized treatment but does not provide exact dose and temporal control.Antiproliferative drugs such as doxorubicine and antisense oligonucleotides have been shown to be promisingin treating proliferative diseases. However, the low cellular uptake of the drugs keeps them from being fullysuccessful. This proposal respondsto the need for an engineering device that provides controlled and highly efficient delivery of drugs. Theprimary goal in this exploratory stage is to develop and demonstrate amicro-electro-mechanicalsystems (MEMS) based drug delivery device that (1) controls the release of drugsfrom the micro device and (2) increases the cell uptake of the agents using an on-chip ultrasound actuator.
Program
Strategic Projects - Group
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
350349-2007
Name nom
Chiao, Mu
Department département
Mechanical Engineering
Organization id
2
Institution établissement
University of British Columbia
Province en
British Columbia
Province fr
Colombie-Britannique
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2007
Competition year année de concours
2007
Award amount
112690
Program id
STPGP
Program name en
Strategic Projects - Group
Program name fr
Projets stratégiques - De groupe
Group en
Research partnerships programs
Group fr
Programmes de partenariat
Committee code
1042
Committee name en
Strategic Projects Selection Panel - Biomedical Technologies
Committee name fr
Comité de sélection des projets stratégiques - Technologies biomédicales
Area of application code
1102
Area of application group en
Health, education and social services
Area of application group fr
Santé publique, éducation et services sociaux
Area of application en
Biomedical engineering
Area of application fr
Génie biomédical
Research subject code
1901
Research subject group en
Biomedical engineering
Research subject group fr
Génie biomédical
Research subject en
Biomedical technology
Research subject fr
Technologie biomédicale
Partie
1
Nb partie
3
Application title
MEMS-based drug delivery devices
Keyword
NA
Application summary
Localized, controlled drug release has gained clinical relevance in treating proliferative diseases in the past decade. The rapidly proliferating cells can keep systemic antiproliferative drugs from entering the capillary networks in the tissue. As a result, many proliferative diseases, such as diabetic retinopathy do not respond well to systemic drug administration. State-of-the-artpolymeric-based drug delivery systems can be intraocularly injected to provide localized treatment but does not provide exact dose and temporal control.Antiproliferative drugs such as doxorubicine and antisense oligonucleotides have been shown to be promisingin treating proliferative diseases. However, the low cellular uptake of the drugs keeps them from being fullysuccessful. This proposal respondsto the need for an engineering device that provides controlled and highly efficient delivery of drugs. Theprimary goal in this exploratory stage is to develop and demonstrate amicro-electro-mechanicalsystems (MEMS) based drug delivery device that (1) controls the release of drugsfrom the micro device and (2) increases the cell uptake of the agents using an on-chip ultrasound actuator.
