Grant: Travel Awards - Institute Community Support
Institut de recherches cliniques de Montréal
$1,500.00
Could the Interleukin 1-beta System Mediate The Relation Of Apob-lipoproteins To Insulin Resistance And Hyperinsulinemia In Obese Subjects?
FY 2014-15
Summary
We research on the mechanisms leading to type 2 diabetes. It is known that a defect in the role of insulin, whether by it's secretion by the pancreas or by the quality of it's action on the cells (insulin resistance), can lead to type 2 diabetes. Furthermore, many teams, including our own, have shown that an increase in a protein involved in cholesterol metabolism is an indicator for a higher risk to develop type 2 diabetes. We even recently showed that this relation is at least partly because this protein induces a malfunction in adipose tissue. Thus, we better caracterized this relation by looking at a human cohort study, in which we show that high levels of this protein are associated with insulin resistance and also interleukin 1-beta, an inflammatory marker.
Department
Program
Travel Awards - Institute Community Support
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
324376
Name
Bissonnette Simon
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Clinical
Prcname2
Institute of Nutrition, Metabolism and Diabetes
Projecttitle
Could the Interleukin 1-beta System Mediate The Relation Of Apob-lipoproteins To Insulin Resistance And Hyperinsulinemia In Obese Subjects?
Programtype2
Undefined
Orgnameinp2
Institut de recherches cliniques de Montréal
Cihramount2
$1,500
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Apob-Lipoproteins; Hyperinsulinemic Euglycemic Clamp; Insulin Resistance; Insulin Secretion; Interleukin-1beta; Intravenous Glucose Tolerance Test; Obesity; Type 2 Diabetes
Abstract
We research on the mechanisms leading to type 2 diabetes. It is known that a defect in the role of insulin, whether by it's secretion by the pancreas or by the quality of it's action on the cells (insulin resistance), can lead to type 2 diabetes. Furthermore, many teams, including our own, have shown that an increase in a protein involved in cholesterol metabolism is an indicator for a higher risk to develop type 2 diabetes. We even recently showed that this relation is at least partly because this protein induces a malfunction in adipose tissue. Thus, we better caracterized this relation by looking at a human cohort study, in which we show that high levels of this protein are associated with insulin resistance and also interleukin 1-beta, an inflammatory marker.
Competitiondate
201501
Approvedterm2
1 yr 0 mth
Pinamesdelim
Bissonnette, Simon
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Nutr Metabolism &Diab~ $1,500~ $0~
