Grant: Operating Grant
University of British Columbia
$678,356.00
Molecular Characterization of P4-ATPases and Their Role in Membrane Lipid Asymmetry, Photoreceptor Cell Structure and Function, and Retinal Degenerative Diseases.
FY 2009-10
Summary
Phospholipids are known to be asymmetrical distributed across biological membranes. This asymmetry plays a crucial role for a wide variety of cellular processes including membrane fusion and vesicle trafficking, aging, cell survival, phagocytosis and general membrane associated protein activities. P4-ATPases are a class of membrane proteins which have been implicated in the generation and maintenance of phospholipid asymmetry, but to date little is known about their structure, function or regulation in cells. In this proposal the P4-ATPase, Atp8a2, will be purified and characterized in order to define its role in photoreceptor cell function and retinal degenerative diseases.
Department
Program
Operating Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
201522
Name
Molday Robert S
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Cell Physiology
Projecttitle
Molecular Characterization of P4-ATPases and Their Role in Membrane Lipid Asymmetry, Photoreceptor Cell Structure and Function, and Retinal Degenerative Diseases.
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$678,356
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Enzymatic Activities; Membrane Proteins; Membrane Reconstitution; P4-Atpases; Phospholipid Asymmetry; Photoreceptor Cells; Protein Characterization; Protein Purification; Proteomics; Retinal Degenerative Diseases
Abstract
Phospholipids are known to be asymmetrical distributed across biological membranes. This asymmetry plays a crucial role for a wide variety of cellular processes including membrane fusion and vesicle trafficking, aging, cell survival, phagocytosis and general membrane associated protein activities. P4-ATPases are a class of membrane proteins which have been implicated in the generation and maintenance of phospholipid asymmetry, but to date little is known about their structure, function or regulation in cells. In this proposal the P4-ATPase, Atp8a2, will be purified and characterized in order to define its role in photoreceptor cell function and retinal degenerative diseases.
Competitiondate
201003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Molday, Robert S
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $678,356~ $0~
