Grant: Project Grant
University of Alberta
$100,000.00
Development of inhibitors of Ubc13 and USP7 and assessment of their impact on cancer cell signaling
FY 2016-17
Summary
Cancer cells are distinguished from normal cells by their ability to grow and survive under conditions where normal cells cannot. The aberrant survival of cancer cells appears to be due to the activation of natural systems within cells that help all cells respond to stress. The difference in cancer cells appears to be that these pro-survival systems become hyper-active and essentially stuck in the "on" position. We have studied a protein called Ubc13 that is essential to two of these pro-survival systems. Our goal is to find a way to specifically block Ubc13 as a way to treat cancers that rely on Ubc13. In preliminary work, we have already identified a small chemical compound that has the ability to specifically block Ubc13. We set out a plan to modify and develop this chemical to improve its specificity and activity on Ubc13, and to test the effectiveness of these compounds to block pro-survival systems in cellular models of human cancer.
Department
Program
Project Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
366582
Name
Glover J. N. Mark
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Development of inhibitors of Ubc13 and USP7 and assessment of their impact on cancer cell signaling
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Dna Damage Signaling,; Lys63 Polyubiquitination; Nf-Kb Signaling; Protein Ubiquitination; Rational Drug Design; Structural Biology; Ubc13; Usp7; X-Ray Crystallography
Abstract
Cancer cells are distinguished from normal cells by their ability to grow and survive under conditions where normal cells cannot. The aberrant survival of cancer cells appears to be due to the activation of natural systems within cells that help all cells respond to stress. The difference in cancer cells appears to be that these pro-survival systems become hyper-active and essentially stuck in the "on" position. We have studied a protein called Ubc13 that is essential to two of these pro-survival systems. Our goal is to find a way to specifically block Ubc13 as a way to treat cancers that rely on Ubc13. In preliminary work, we have already identified a small chemical compound that has the ability to specifically block Ubc13. We set out a plan to modify and develop this chemical to improve its specificity and activity on Ubc13, and to test the effectiveness of these compounds to block pro-survival systems in cellular models of human cancer.
Competitiondate
201611
Approvedterm2
1 yr 0 mth
Pinamesdelim
Glover, J. N. Mark
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
