Grant: Operating Grant
Université de Sherbrooke
$688,318.00
Regulation and role of the ERK signalling in colorectal carcinogenesis
FY 2011-12
Summary
Colorectal cancer (CRC) is one of the most common forms of cancer in Canada. One in 14 men is expected to develop colorectal cancer during his lifetime and one in 27 will die of it. Since the entire intestinal tissue is in a constant state of renewal, such turnover involves a countless number of cell divisions, hence a non-negligible risk of genetic alterations. This rapid rate of intestinal tissue renewal as well as exposure to toxic substances, notably through food ingestion, may explain the high prevalence of CRC. Mutations have been identified in K-Ras and B-Raf in patients with colorectal cancer. Ras and Raf proteins are two major players in the MAP kinase pathway. They are crucial downstream regulators of multiple receptor tyrosine kinase-mediated cell growth, transformation, and maintenance of the malignant phenotype in human cancers.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
238696
Name
Rivard Nathalie
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Molecular & Cellular Biology of Cancer
Projecttitle
Regulation and role of the ERK signalling in colorectal carcinogenesis
Programtype2
Operating Grants
Orgnameinp2
Université de Sherbrooke
Cihramount2
$688,318
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cellular And Molecular Biology; Conditional Knockout/Knockin Mice; Intestinal Epithelium; Map Kinase Phosphatase; Map Kinase Signalling; Ras/Raf Oncogenes; Tumorigenesis
Abstract
Colorectal cancer (CRC) is one of the most common forms of cancer in Canada. One in 14 men is expected to develop colorectal cancer during his lifetime and one in 27 will die of it. Since the entire intestinal tissue is in a constant state of renewal, such turnover involves a countless number of cell divisions, hence a non-negligible risk of genetic alterations. This rapid rate of intestinal tissue renewal as well as exposure to toxic substances, notably through food ingestion, may explain the high prevalence of CRC. Mutations have been identified in K-Ras and B-Raf in patients with colorectal cancer. Ras and Raf proteins are two major players in the MAP kinase pathway. They are crucial downstream regulators of multiple receptor tyrosine kinase-mediated cell growth, transformation, and maintenance of the malignant phenotype in human cancers.
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Rivard, Nathalie
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $688,318~ $0~
