Grant: Operating Grant
Children's Hospital of Eastern Ontario Research Institute Inc
$583,550.00
Translation regulation of the inhibitor of apoptosis, cIAP1, during cellular stress.
FY 2009-10
Summary
My research program involves the study of the regulation of gene expression at the level of protein synthesis (translation), in particular how it is regulated during conditions of cellular stress. We have discovered that there exists an alternative mode of translation that utilizes an RNA regulatory element termed IRES. Importantly, this mode of translation persists during conditions of stress when normal cellular protein synthesis is shut down. I propose here to continue our analysis of the IRES mechanism of translation during conditions of cellular stress.
Department
Program
Operating Grant
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
188785
Name
Holcik Martin
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
Translation regulation of the inhibitor of apoptosis, cIAP1, during cellular stress.
Programtype2
Operating Grants
Orgnameinp2
Children's Hospital of Eastern Ontario Research Institute Inc
Cihramount2
$583,550
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Apoptosis; Cancer; Internal Ribosome Entry Site; Rna Binding Proteins; Signal Transduction; Translational Control
Abstract
My research program involves the study of the regulation of gene expression at the level of protein synthesis (translation), in particular how it is regulated during conditions of cellular stress. We have discovered that there exists an alternative mode of translation that utilizes an RNA regulatory element termed IRES. Importantly, this mode of translation persists during conditions of stress when normal cellular protein synthesis is shut down. I propose here to continue our analysis of the IRES mechanism of translation during conditions of cellular stress.
Competitiondate
200909
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Holcik, Martin
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $583,550~ $0~
