Grant: Project Grant

Intestinal inflammation due to infection or diseases like inflammatory bowel disease causes great deal of morbidity and mortality. Our recent work has uncovered a novel pathway in the intestine that protects against infection. Interesting also is that dysregulation of this pathway has been implicated in the inflammatory bowel disease, Crohn's disease. By studying this circuit in the context of infection, we also expect to uncover novel insights into the pathogenesis of Crohn's disease Furthermore, this work will help to define new therapeutic targets that might treat both Crohn's disease and infection.