Grant: Operating Grant
McGill University
$477,730.00
Mechanisms underlying diaphragm weakness induced by mechanical ventilation
FY 2013-14
Summary
Mechanical ventilation (MV) is a life-saving procedure for patients with respiratory failure. Unfortunately, MV may also trigger dysfunction of ventilatory muscles. In the diaphragm, MV results in ventilatory-induced diaphragm dysfunction (VIDD). We currently do not know the mechanisms responsible for muscle dysfunction caused by MV, but there is evidence that it may be related to loss of contractile force. In this study, we will investigate the mechanism behind VIDD in the diaphragm to gain insight into potential targets for treatment and patient's recovery.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
292358
Name
Rassier Dilson E
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Respiratory System
Projecttitle
Mechanisms underlying diaphragm weakness induced by mechanical ventilation
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$477,730
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Diaphragm Physiology; Mechanical Ventilation
Abstract
Mechanical ventilation (MV) is a life-saving procedure for patients with respiratory failure. Unfortunately, MV may also trigger dysfunction of ventilatory muscles. In the diaphragm, MV results in ventilatory-induced diaphragm dysfunction (VIDD). We currently do not know the mechanisms responsible for muscle dysfunction caused by MV, but there is evidence that it may be related to loss of contractile force. In this study, we will investigate the mechanism behind VIDD in the diaphragm to gain insight into potential targets for treatment and patient's recovery.
Competitiondate
201309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Rassier, Dilson E; Hussain, Sabah N
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $477,730~ $0~
