Grant: CIHR Fellowship
Centre for Addiction and Mental Health (Toronto)
$210,000.00
Leveraging big data to assess hormonal and psychological factors affecting cognition and dementia risk across the menopausal transition
FY 2024-25
Summary
It is well-established that hormonal changes in menopause are associated with variance in brain aging. As such, the menopausal transition presents a key research avenue for understanding why women are more likely to develop Alzheimer's disease (AD) than men. The proposed project will leverage big datasets of women currently experiencing transition into menopause as well as postmenopausal women (total N = 50,000) in order to study the association between menopause symptoms, hormone therapy, and cognition in women along a continuum of risk for AD: healthy perimenopausal women, healthy postmenopausal women, postmenopausal women with amnestic mild cognitive impairment (a major risk state for AD), and postmenopausal women with AD. We will examine subjective reports of cognitive function, objective neuropsychological tests, and neuroimaging findings in order to provide a comprehensive account of women's cognitive aging across the menopausal transition and at varying levels of cognitive decline. Furthermore, our large-scale evaluation of the effects of hormone therapy on cognitive aging may help inform potential preventative treatments for AD in women.
Department
Program
CIHR Fellowship
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
513380
Name
Perovic Mateja
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Gender and Health
Theme2
Biomedical
Prcname2
Health Research Training A - Post-PhD (HTA)
Projecttitle
Leveraging big data to assess hormonal and psychological factors affecting cognition and dementia risk across the menopausal transition
Programtype2
Fellowship Programs
Orgnameinp2
Centre for Addiction and Mental Health (Toronto)
Cihramount2
$210,000
Cihrequipment2
$0
Programname2
CIHR Fellowship
Keyworddelim
Cognition; Cognitive Aging; Estradiol; Hormone Therapy; Menopause; Mild Cognitive Impairment; Mood; Perimenopause; Vasomotor Symptoms; Women'S Health
Abstract
It is well-established that hormonal changes in menopause are associated with variance in brain aging. As such, the menopausal transition presents a key research avenue for understanding why women are more likely to develop Alzheimer's disease (AD) than men. The proposed project will leverage big datasets of women currently experiencing transition into menopause as well as postmenopausal women (total N = 50,000) in order to study the association between menopause symptoms, hormone therapy, and cognition in women along a continuum of risk for AD: healthy perimenopausal women, healthy postmenopausal women, postmenopausal women with amnestic mild cognitive impairment (a major risk state for AD), and postmenopausal women with AD. We will examine subjective reports of cognitive function, objective neuropsychological tests, and neuroimaging findings in order to provide a comprehensive account of women's cognitive aging across the menopausal transition and at varying levels of cognitive decline. Furthermore, our large-scale evaluation of the effects of hormone therapy on cognitive aging may help inform potential preventative treatments for AD in women.
Competitiondate
202410
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Perovic, Mateja
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $210,000~ $0~
