Grant: CIHR Fellowship
Direct Payment
$150,000.00
Epigenetic regulation of cardiac hypertrophy by BET acetyl-lysine binding proteins
FY 2016-17
Summary
In response to stresses such as heart attack or high blood pressure, the heart grows through an enlargement of the heart muscle - a process called cardiac hypertrophy. Although cardiac hypertrophy initially helps the heart pump blood more effectively, long term cardiac hypertrophy ultimately leads to heart failure. Patients with heart failure have shortness of breath, fluid retention and an inability to exercise. Furthermore, someone who has heart failure has a ~40% chance of dying within 5 years of the diagnosis. This research proposal is designed to more clearly define the molecular mechanisms that control cardiac hypertrophy, with the long term goal of developing new drugs to treat humans with heart failure.
Department
Program
CIHR Fellowship
Recipient
Location
Colorado, United States of America
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
361494
Name
Bagchi Rushita A
Region
Colorado
Country
United States of America
Orgtype
Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Fellowships - Post-PhD
Projecttitle
Epigenetic regulation of cardiac hypertrophy by BET acetyl-lysine binding proteins
Programtype2
Fellowship Programs
Orgnameinp2
Direct Payment
Cihramount2
$150,000
Cihrequipment2
$0
Programname2
CIHR Fellowship
Keyworddelim
Bromodomain; Cardiac Hypertrophy; Echocardiography; Epigenetics; Gene Transcription; Heart Failure; High-Throughput Screening; Myocardial Infarction; Pre-Clinical Model; Whole Genome Chip Seq
Abstract
In response to stresses such as heart attack or high blood pressure, the heart grows through an enlargement of the heart muscle - a process called cardiac hypertrophy. Although cardiac hypertrophy initially helps the heart pump blood more effectively, long term cardiac hypertrophy ultimately leads to heart failure. Patients with heart failure have shortness of breath, fluid retention and an inability to exercise. Furthermore, someone who has heart failure has a ~40% chance of dying within 5 years of the diagnosis. This research proposal is designed to more clearly define the molecular mechanisms that control cardiac hypertrophy, with the long term goal of developing new drugs to treat humans with heart failure.
Competitiondate
201611
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Bagchi, Rushita A
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $150,000~ $0~
