Grant: Operating Grant
University of Toronto
$959,057.00
The TAR DNA-Binding Protein (TDP-43) and Amyotrophic Lateral Sclerosis
FY 2013-14
Summary
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating neurodegenerative diseases that share a number of commonalities. One major commonality is the presence of abnormal accumulations of a protein called TDP-43 in the brain and spinal cord of affected individuals. We are trying to understand how these abnormalities of TDP-43 occur and how they contribute to the disease process. We have already made major strides through the development of new disease models and use of cutting edge technologies to uncover an important disease pathway that links not only ALS and FTD, but also Alzheimer's and Parkinson's disease. Through further investigation we hope to establish this link with the aim of gaining a fuller understanding of the mechanistic basis of how TDP-43 is related to disease causation. It is through this that we hope to develop effective treatments.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
305508
Name
Robertson Janice
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Systems & Circuits Neurosciences - A
Projecttitle
The TAR DNA-Binding Protein (TDP-43) and Amyotrophic Lateral Sclerosis
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$959,057
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Amyotrophic Lateral Sclerosis; Neuropathology; Protein Biochemistry; Tar-Dna-Binding Protein; Transgenic Mice; Ubiquitinated Inclusions
Abstract
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating neurodegenerative diseases that share a number of commonalities. One major commonality is the presence of abnormal accumulations of a protein called TDP-43 in the brain and spinal cord of affected individuals. We are trying to understand how these abnormalities of TDP-43 occur and how they contribute to the disease process. We have already made major strides through the development of new disease models and use of cutting edge technologies to uncover an important disease pathway that links not only ALS and FTD, but also Alzheimer's and Parkinson's disease. Through further investigation we hope to establish this link with the aim of gaining a fuller understanding of the mechanistic basis of how TDP-43 is related to disease causation. It is through this that we hope to develop effective treatments.
Competitiondate
201403
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Robertson, Janice
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $959,057~ $0~
