Grant: Operating Grant
Université de Sherbrooke
$553,311.00
Regulation of G protein-coupled receptors by their cognate alternative proteins
FY 2013-14
Summary
About a thousand human genes (5% of the genome) code for G protein-coupled receptors (GPCRs) which help channel vital information into the cells of just about every organ system. GCPRs are involved in a multitude of diseases, including cancer, cardiovascular diseases and diabetes, respectively the 1st, 2nd and 6th causes of death in Canada. Members of the GPCR protein family are thus important pharmacological targets. Leading experts believe GPCRs will remain at the center stage of drug development activities for the foreseeable future.
This proposal focuses on the functional characterization of a novel protein co-expressed with the bradykinin B2 receptor, from the same gene, and its impact on the functional regulation of its ubiquitously and constitutively expressed GPCR cognate, B2R.
B2R is an important pro-inflammatory receptor that causes vasodilation, plasma protein extravasation, smooth muscle contraction and pain. Results are expected to shed light on B2R regulation and the potential of AltB2R as novel therapeutic target in cardiovascular and renal diseases.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
304827
Name
Roucou Xavier
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Cell Physiology
Projecttitle
Regulation of G protein-coupled receptors by their cognate alternative proteins
Programtype2
Operating Grants
Orgnameinp2
Université de Sherbrooke
Cihramount2
$553,311
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Bradykinin; Cell Signalling; Endocytosis; Endoplasmic Retisulum; G Protein Coupled Receptor; Gst Pull Down; Ligand Binding; Mass Spectrometry
Abstract
About a thousand human genes (5% of the genome) code for G protein-coupled receptors (GPCRs) which help channel vital information into the cells of just about every organ system. GCPRs are involved in a multitude of diseases, including cancer, cardiovascular diseases and diabetes, respectively the 1st, 2nd and 6th causes of death in Canada. Members of the GPCR protein family are thus important pharmacological targets. Leading experts believe GPCRs will remain at the center stage of drug development activities for the foreseeable future.
This proposal focuses on the functional characterization of a novel protein co-expressed with the bradykinin B2 receptor, from the same gene, and its impact on the functional regulation of its ubiquitously and constitutively expressed GPCR cognate, B2R.
B2R is an important pro-inflammatory receptor that causes vasodilation, plasma protein extravasation, smooth muscle contraction and pain. Results are expected to shed light on B2R regulation and the potential of AltB2R as novel therapeutic target in cardiovascular and renal diseases.
Competitiondate
201403
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Roucou, Xavier
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $553,311~ $0~
