Grant: Canada Postdoctoral Research Award (CPRA) program
University of British Columbia
$140,000.00
Genetic and environmental factors in brain cell development
FY 2025-26
Summary
Neurodevelopmental disorders (NDDs) result from a complex interplay between our genes and our surroundings. We do not know the exact mechanisms. We do know that chemical attachments to the DNA (=epigenetics) reflect the interplay between genes and our surrounding. We also known that smoking during pregnancy increases the risk for NDDs. We want to study whether smoking is causing NDDs, or whether smoking occurs more often in mothers of children with NDDs because of shared genetics. In this project, I will use a novel approach to examine epigenetic patterns in advanced cell models. This will help us clarify the molecular mechanisms causing NDDs, which will ultimately improve prevention and intervention strategies for NDDs.
Department
Program
Canada Postdoctoral Research Award (CPRA) program
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
536904
Name
Meijer Mandy
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Canada Postdoctoral Research Award - A
Projecttitle
Genetic and environmental factors in brain cell development
Programtype2
Fellowship Programs
Orgnameinp2
University of British Columbia
Cihramount2
$140,000
Cihrequipment2
$0
Programname2
Canada Postdoctoral Research Award (CPRA) program
Keyworddelim
Brain Development; Cell Culture; Environmental Exposure; Epigenetics; Genetic Variants; Microglia; Next Generation Sequencing
Abstract
Neurodevelopmental disorders (NDDs) result from a complex interplay between our genes and our surroundings. We do not know the exact mechanisms. We do know that chemical attachments to the DNA (=epigenetics) reflect the interplay between genes and our surrounding. We also known that smoking during pregnancy increases the risk for NDDs. We want to study whether smoking is causing NDDs, or whether smoking occurs more often in mothers of children with NDDs because of shared genetics. In this project, I will use a novel approach to examine epigenetic patterns in advanced cell models. This will help us clarify the molecular mechanisms causing NDDs, which will ultimately improve prevention and intervention strategies for NDDs.
Competitiondate
202509
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Meijer, Mandy
Approvedterm
2 ans 0 mois
Cihrcontribution2
~ $140,000~ $0~
