Grant: Operating Grant
University of British Columbia
$763,635.00
Metabolic regulation by a network centered on a conserved Mediator subunit
FY 2008-09
Summary
Like all organisms, humans must adapt to changing conditions. Failure to do so can cause health problems; for example, inappropriate responses to food intake can cause diabetes and obesity, which are global health concerns today. These metabolic diseases are caused by a myriad of genetic and environmental factors. Accordingly, the pathways that assure normal metabolism are very complex. Fortunately, such mechanisms are conserved in lower animals to a significant extent. Thus, I want to exploit the genetically tractable roundworm Caenorhabditis elegans to discover and characterize new regulators that control lipid biology and the response to nutrition-related stresses. I will focus on a protein, called MDT-15, which plays a key role in the regulation of these processes. Importantly, this protein has a relative in humans, so I can potentially learn about human metabolic regulation by studying a model organism. In summary, I shall identify and characterize new genes and pathways that contribute to human (metabolic) disease. This work will add significantly to our knowledgebase of pathways regulating metabolism, and - in the long term - may aid the development of new preventative and/or therapeutic strategies.
Department
Program
Operating Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
172816
Name
Taubert Stefan
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
Metabolic regulation by a network centered on a conserved Mediator subunit
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$763,635
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Gene Expression/ Transcription; Genetics Of Regulatory Networks; Lipid Metabolism; Stress Response / Detoxification
Abstract
Like all organisms, humans must adapt to changing conditions. Failure to do so can cause health problems; for example, inappropriate responses to food intake can cause diabetes and obesity, which are global health concerns today. These metabolic diseases are caused by a myriad of genetic and environmental factors. Accordingly, the pathways that assure normal metabolism are very complex. Fortunately, such mechanisms are conserved in lower animals to a significant extent. Thus, I want to exploit the genetically tractable roundworm Caenorhabditis elegans to discover and characterize new regulators that control lipid biology and the response to nutrition-related stresses. I will focus on a protein, called MDT-15, which plays a key role in the regulation of these processes. Importantly, this protein has a relative in humans, so I can potentially learn about human metabolic regulation by studying a model organism. In summary, I shall identify and characterize new genes and pathways that contribute to human (metabolic) disease. This work will add significantly to our knowledgebase of pathways regulating metabolism, and - in the long term - may aid the development of new preventative and/or therapeutic strategies.
Competitiondate
200809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Taubert, Stefan
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $763,635~ $0~
